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© 2010 Eye Strain - An attempt to cure
From here: http://allaboutdryeye.com/2011/12/16/learn-how-to-treat-dry-eye-with-vitamin-a/
A study done by the Division of Ophthalmology at Kansai Rosai Hospital in Hyogo, Japan treated 12 patients with topical Vitamin A eye drops to treat superior limbic keratoconjunctivitis patients for three months with outstanding results – 10 patients or 83% saw no recurrence. Other studies have found that preservative-free Vitamin A drops can help substantially in treating dry eye symptoms, some even better than more expensive prescription drops[1].
Vitamin A also have been shown effective for the treatment of the following eye diseases: superior limpic keratoconjunctivitis, age-related macular degeneration (AMD), retinitis pigmentosa (RP), loss of peripheral vision, Stargardt’s disease.
[1] Ophthalmologica: 1997;211(6):358-61.Effect of retinol palmitate as a treatment for dry eye: a cytological evaluation
What are plant sterols?
Plant sterols (or phytosterols) are a naturally occurring part of all plants. They are mainly found in vegetable oils but are also present in smaller amounts in nuts, legumes, grains, cereals, wood pulp and leaves. The main sources of plant sterols added to foods in Australia are soybean oil or tall (pine) oil. [Source]
What are steroids?
Steroids are organic compounds found throughout the plant and animal kingdoms. They include hormones such as testosterone and estrogen and the lipid cholesterol. Anabolic steroids, which are used by some athletes as performance enhancers, are not in the same chemical family. In plants, steroids are important chemicals that stimulate growth. These growth hormones have been researched both for their natural function and their potential as crop-boosters.[Source]
Plant Steroids Vs. Other Steroids
Like in humans and animals, plant steroids send signals to boost growth. Additionally, brassinosteroids assist in cell differentiation. They help stem cells — cells that have not yet found a function — become assigned to their proper areas. However, "ScienceDaily" explains that plant sterioids "function very differently at the cellular level." Plant and animal cells have receptors that detect steroids. The fundamental difference is that these receptors are found in the nucleus of animal cells, while plant receptors are on the cells' outside membranes. [ibid]
Aloe vera
Contains these sterols: lupeol, campesterol, and βsitosterol [Source]
The antiinflammatory activity of Aloe Vera Gel has been revealed by a number of in vitro and in vivo studies (See studies section). Fresh Aloe Vera Gel significantly reduced acute inflammation in rats (carrageenininduced paw oedema), although no effect on chronic inflammation was observed. Aloe Vera Gel appears to exert its anti inflammatory activity through bradykinase activity and thromboxane B2 and prostaglandin F2 inhibition. Furthermore, three plant sterols in Aloe Vera Gel reduced inflammation by up to 37% in croton oilinduced oedema in mice. Lupeol, one of the sterol compounds found in Aloe Vera, was the most active and reduced inflammation in a dosedependent manner. These data suggest that specific plant sterols may also contribute to the antiinflammatory activity of Aloe Vera Gel.
Aloe contains a broad spectrum of free amino acids, free monosaccharides, and total saccharides released upon hydrolysis, sterols (mainly B-sitosterol) plus lupeol. Note: B-sitosterol is a powerful anti-inflammatory and anti-cholesterolmatic. Lupeol is a powerful pain killer and anti-microbial.
Aloe Vera contains at least three anti-inflammatory fatty acids, cholesterol, campersterol and B-sitosterol (plant sterols) which explains why it is a highly effective treatment for burns, cuts, scrapes, abrasions, allergic reactions, rheumatoid arthritis, rheumatic fever, acid indigestion, ulcers, plus many inflammatory conditions of the digestive system and other internal organs, including the stomach, small intestine, colon, liver, kidney, and pancreas. B-sitosterol is also a powerful anti-cholestromatic which helps to lower harmful cholesterol levels, helping to explain its many benefits for heart patents.
[Source]
Before sleeping I put in castor oil and ointments to dull the pain. Last night (4 Dec 2011) I got up but couldn’t go back to sleep because of intense burning pain. I tried putting an ointment as well as castor oil, to no effect. I tried thera tears gel. No effect. Then put honey. No effect. Finally tried aloe vera. Finally some temporary relief.
Why does aloe vera have a "cooling" effect on burning eyes?
Some possible answers:
Plant sterols, like steroid drugs, have an anti-inflammatory effect. However, steroids inhibit “healing” or tissue regeneration- which conversely Aloe vera promotes. Dr. Robert Davis found the natural sterols having the strongest anti inflammatory effect in Aloe vera are- lupeol, beta sitosterol, and campesterol. (3) (4)3. Davis R, Donato S, et al. Anti-inflammatory and wound healing activity of a growth substance in aloe vera. J Am Podiatr Med Assoc. 1994;84(2):77-814. Davis, RH: Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. J of Am Podiatric Medical Assoc, 84(12), December, 1994, pp 614-619.
Here's an interesting website: http://www.aloeplant.info/aloe-vera-for-the-eyes-and-ears/
It also works on skin, and if applied on the hair reduces dandruff (apparently – haven't tried it).
Napoleon had no army hospital but a horse-drawn wagon of aloe vera for the benefit of his soldiers [Source]
How to make Aloe Vera eye drops
To make eye drops, dissolve half a teaspoon of aloe vera gel powder into one cup of water. Filter first before putting into the eye. Your eyes will be clean from dust and dirt. [Source]
To create an eyewash, dissolve ½ tsp of powdered aloe gel in one cup of water. To accelerate the healing process add one teaspoon of boric acid. Pour the solution through a coffee filter before applying to the eyes. [Source]
Eat aloe vera leaves raw
Here's a surprise piece of info: http://www.everydayhealth.com/profile/kcchhan
Here's more: http://www.aloe-vera-and-handy-herbs.com/eat-your-aloe-vera.html
How to make an Aloe vera smoothie
http://www.naturalnews.com/021858.html (a really comprehensive article)
"Aloe vera halts inflammation: Using aloe topically is well known to ease inflammation of joints, reducing arthritis pain. But aloe can also be used internally, reducing inflammation throughout the body from the inside out. People who drink aloe vera for two weeks typically begin to experience a significant reduction of inflammation symptoms. or a list of studies and references,click here."
How to cook aloe vera
http://www.ehow.com/how_5620161_cook-aloe.html
How to poach Aloe vera – recipe
http://norecipes.com/blog/2009/05/20/poached-aloe-recipe/
More stuff: http://www.your-health-and-wellness-guide.com/Aloe-Vera.html
and http://health.centreforce.com/health/aloe.html
#1. Aloe vera “Shoots” A Messenger of Pain Called Bradykinin
Bradykinin is part of the body’s complex mechanism that causes painful inflammation. In studies, Aloe vera has been shown to possess anti-bradykinin activity. Aloe vera contains the enzyme bradykinase, which breaks down bradykinin (1)(2). In this regard, Aloe vera can help knee pain, backpain, shoulder pain or other joint pain.
#2. Aloe vera Contains Plant Sterols That Are Powerful
Anti-inflammatory Agents
Anti-inflammatory Agents
Plant sterols, like steroid drugs, have an anti-inflammatory effect. However, steroids inhibit “healing” or tissue regeneration- which conversely Aloe vera promotes. Dr. Robert Davis found the natural sterols having the strongest anti inflammatory effect in Aloe vera are- lupeol, beta sitosterol, and campesterol. (3) (4)
#3. Aloe vera Contains an Aspirin Like Substance Called Salicylic Acid
Salicylic acid has pain relieving properties and reduces inflammation by inhibiting the production of prostaglandin hormones- which encourage inflammation. Aspirin or “acetylsalicylic acid” is chemically derived from natural salicylic acid. And we know, unlike aspirin, Aloe vera does not hurt your stomach or digestion- actually it helps it. Aloe vera may help knee pain, shoulder pain, back pain or other joint pain.
#4. Aloe vera Has a COX-2 Inhibiting Effect
Researchers in Mexico found that Aloe vera inhibits cyclooxygenase (COX-2), an enzyme that causes inflammation via the arachidonic acid pathway. Again, it does this without causing the unwanted side-effects of the COX-2 drugs.(5). Again, this may help your knee pain, back pain, shoulder pain or other joint pain.
#5. Aloe vera “Fixes” Digestion and Bowel Function- Overlooked
Causes of “Silent Inflammation”
Causes of “Silent Inflammation”
Impaired digestion and poor absorption of proteins creates “foreign” invaders that your body views as a threat and seeks “protection” through inflammation. This “auto-immune” response ultimately results in conditions such as Rheumatoid arthritis, Irritable Bowel Syndrome (IBS), Crohn's disease and Colitis.
A study by Dr. Jeffrey Bland(6) showed how taking Aloe Vera internally improves protein digestion/absorption, balances acid levels, improves colonic activity and lowers bowel putrefaction- in just one week. By improving digestion and elimination, you help reduce chronic inflammation, potentially improving knee pain, back pain, shoulder pain and other joint pain.
#6. Aloe Polysaccharides Stimulate Fibroblasts
Which Grow and Repair Tissue
Which Grow and Repair Tissue
The “miracle” of Aloe is that it uniquely can reduce inflammation and promote tissue regeneration- which by itself helps reduce inflammation. Dr. Davis and Dr. Ivan Danhoff have shown that Aloe polysaccharides (long chain sugar molecules) stimulate fibroblasts that promote the tissue regrowth. But to do this, the polysaccharides need to be in the presence of the other Aloe nutrients- another reason why you want whole leaf aloe vera.
The polysaccharides also help the immune system remove toxic waste which has an anti-inflammatory benefit.
- "Bradykinase Activity in Aloe Extract: Fujita, K., Teradaira, R. & Nagatsu, T., BiochemicalPharmacology 25 205, 1976.
- Bautista-Perez R, Segura-Cobos D, Vasquez-Cruz B. In vitro antibradykinin activity of Aloe barbadensis gel. J Ethnopharmacol. July 2004;93(1):89-92.
- Davis R, Donato S, et al. Anti-inflammatory and wound healing activity of a growth substance in aloe vera. J Am Podiatr Med Assoc. 1994;84(2):77-81.
- Davis, RH: Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. J of Am Podiatric Medical Assoc, 84(12), December, 1994, pp 614-619.
- Vazquez B, Avila G, et al. Anti-inflammatory activity of extracts from Aloe vera gel. J Ethnopharmacol. 1996;55(1):69-75.
- Bland, Jeffrey, “Effect of orally consumed Aloe Vera juice on gastrointestinal function in normal humans”. Preventative Medicine March/April, 1985
Further stuff, from World Health Organisation
Medicinal uses
Uses supported by clinical data
None.
Uses described in pharmacopoeias and in traditional systems of medicine
Aloe Vera Gel is widely used for the external treatment of minor wounds and inflammatory skin disorders (1, 14–17). The gel is used in the treatment of minor skin irritations, including burns, bruises, and abrasions (1, 14, 18). The gel is further used in the cosmetics industry as a hydrating ingredient in liquids, creams, sun lotions, shaving creams, lip balms, healing ointments, and face packs (1).
Aloe Vera Gel has been traditionally used as a natural remedy for burns (18, 19). Aloe Vera Gel has been effectively used in the treatment of first- and second-degree thermal burns and radiation burns. Both thermal and radiation burns healed faster with less necrosis when treated with preparations containing Aloe Vera Gel (18, 19). In most cases the gel must be freshly prepared because of its sensitivity to enzymatic, oxidative, or microbial degradation. Aloe Vera Gel is not approved as an internal medication, and internal administration of the gel has not been shown to exert any consistent therapeutic effect.
Uses described in folk medicine, not supported by experimental or clinical data
The treatment of acne, haemorrhoids, psoriasis, anaemia, glaucoma, petit ulcer, tuberculosis, blindness, seborrhoeic dermatitis, and fungal infections (2, 6, 19).
Pharmacology
Wound healing
Clinical investigations suggest that Aloe Vera Gel preparations accelerate wound healing (14, 18). In vivo studies have demonstrated that Aloe Vera Gel promotes wound healing by directly stimulating the activity of macrophages and fibroblasts (14). Fibroblast activation by Aloe Vera Gel has been reported to increase both collagen and proteoglycan synthesis, thereby promoting tissue repair (14). Some of the active principles appear to be polysaccharides composed of several monosaccharides, predominantly mannose. It has been suggested that mannose 6-phosphate, the principal sugar component of Aloe Vera Gel, may be partly responsible for the wound healing properties of the gel (14). Mannose 6-phosphate can bind to the growth factor receptors on the surface of the fibroblasts and thereby enhance their activity (14, 15).
Furthermore, acemannan, a complex carbohydrate isolated from Aloe leaves, has been shown to accelerate wound healing and reduce radiationinduced skin reactions (20, 21). The mechanism of action of acemannan appears to be twofold. First, acemannan is a potent macrophage-activating agent and therefore may stimulate the release of fibrogenic cytokines (21, 22). Second, growth factors may directly bind to acemannan, promoting their stability and prolonging their stimulation of granulation tissue (20).
The therapeutic effects of Aloe Vera Gel also include prevention of progressive dermal ischaemia caused by burns, frostbite, electrical injury and intraarterial drug abuse. In vivo analysis of these injuries demonstrates that Aloe Vera Gel acts as an inhibitor of thromboxane A2, a mediator of progressive tissue damage (14, 17). Several other mechanisms have been proposed to explain the activity of Aloe Vera Gel, including stimulation of the complement linked to polysaccharides, as well as the hydrating, insulating, and protective properties of the gel (1).
Because many of the active ingredients appear to deteriorate on storage, the use of fresh gel is recommended. Studies of the growth of normal human cells in vitro demonstrated that cell growth and attachment were promoted by exposure to fresh Aloe vera leaves, whereas a stabilized Aloe Vera Gel preparation was shown to be cytotoxic to both normal and tumour cells. The cytotoxic effects of the stabilized gel were thought to be due to the addition of other substances to the gel during processing (23).
Anti-inflammatory
The anti-inflammatory activity of Aloe Vera Gel has been revealed by a number of in vitro and in vivostudies (14, 17, 24, 25). Fresh Aloe Vera Gel significantly reduced acute inflammation in rats (carrageenin-induced paw oedema), although no effect on chronic inflammation was observed (25). Aloe Vera Gel appears to exert its anti-inflammatory activity through bradykinase activity (24) and thromboxane B2 and prostaglandin F2 inhibition (18, 26). Furthermore, three plant sterols in Aloe Vera Gel reduced inflammation by up to 37% in croton oil-induced oedema in mice (15). Lupeol, one of the sterol compounds found in Aloe vera, was the most active and reduced inflammation in a dosedependent manner (15). These data suggest that specific plant sterols may also contribute to the anti-inflammatory activity of Aloe Vera Gel.
Burn treatment
Aloe Vera Gel has been used for the treatment of radiation burns (27–30). Healing of radiation ulcers was observed in two patients treated with Aloe vera cream (27), although the fresh gel was more effective than the cream (29, 30). Complete healing was observed, after treatment with fresh Aloe Vera Gel, in two patients with radiation burns (30). Twenty-seven patients with partialthickness burns were treated with Aloe Vera Gel in a placebo-controlled study (31). The Aloe Vera Gel-treated lesions healed faster (11.8 days) than the burns treated with petroleum jelly gauze (18.2 days), a difference that is statistically significant (t-test, P < 0.002).
Contraindications
Aloe Vera Gel is contraindicated in cases of known allergy to plants in the Liliaceae.
Warnings
No information available.
Precautions
No information available concerning general precautions, or precautions dealing with carcinogenesis, mutagenesis, impairment of fertility; drug and laboratory test interactions; drug interactions; nursing mothers; paediatric use; or teratogenic or non-teratogenic effects on pregnancy.
Adverse reactions
There have been a few reports of contact dermatitis and burning skin sensations following topical applications of Aloe Vera Gel to dermabraded skin (18, 32). These reactions appeared to be associated with anthraquinone contaminants in this preparation (33). A case of disseminated dermatitis has been reported following application of Aloe Vera Gel to a patient with stasis dermatitis (34). An acute bullous allergic reaction and contact urticaria have also been reported to result from the use of Aloe Vera Gel (35).
Posology
Fresh gel or preparations containing 10–70% fresh gel.
References
1. Bruneton J. Pharmacognosy, phytochemistry, medicinal plants. Paris, Lavoisier, 1995.
2. Grindlay D, Reynolds T. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. Journal of ethnopharmacology, 1986, 16:117– 151.
3. Newton LE. In defence of the name Aloe vera. The cactus and succulent journal of Great Britain, 1979, 41:29–30.
4. Tucker AO, Duke JA, Foster S. Botanical nomenclature of medicinal plants. In: Cracker LE, Simon JE, eds. Herbs, spices and medicinal plants, Vol. 4. Phoenix, AR, Oryx Press, 1989:169–242.
5. Hänsel R et al., eds. Hagers Handbuch der Pharmazeutischen Praxis, Vol. 6, 5th ed. Berlin, Springer, 1994.
6. Youngken HW. Textbook of pharmacognosy, 6th ed. Philadelphia, Blakiston, 1950.
7. Quality control methods for medicinal plant materials. Geneva, World Health Organization, 1998.
8. Deutsches Arzneibuch 1996. Vol. 2. Methoden der Biologie. Stuttgart, Deutscher Apotheker Verlag, 1996.
9. European pharmacopoeia, 3rd ed. Strasbourg, Council of Europe, 1997.
10. Rowe TD, Park LM. Phytochemical study of Aloe vera leaf. Journal of the American Pharmaceutical Association, 1941, 30:262–266.
11. Guidelines for predicting dietary intake of pesticide residues, 2nd rev. ed. Geneva, World Health Organization, 1997 (unpublished document WHO/FSF/FOS/97.7; available from Food Safety, WHO, 1211 Geneva 27, Switzerland).
12. Pierce RF. Comparison between the nutritional contents of the aloe gel from conventional and hydroponically grown plants. Erde international, 1983, 1:37–38.
13. Hart LA et al. An anti-complementary polysaccharide with immunological adjuvant activity from the leaf of Aloe vera. Planta medica, 1989, 55:509–511.
14. Davis RH et al. Anti-inflammatory and wound healing of growth substance in Aloe vera. Journal of the American Pediatric Medical Association, 1994, 84:77–81.
15. Davis RH et al. Aloe vera, hydrocortisone, and sterol influence on wound tensile strength and anti-inflammation. Journal of the American Pediatric Medical Association, 1994, 84:614–621.
16. Heggers JP, Pelley RP, Robson MC. Beneficial effects of Aloe in wound healing. Phytotherapy research, 1993, 7:S48–S52.
17. McCauley R. Frostbite-methods to minimize tissue loss. Postgraduate medicine, 1990, 88:67–70.
18. Shelton RM. Aloe vera, its chemical and therapeutic properties. International journal of dermatology, 1991, 30:679–683.
19. Haller JS. A drug for all seasons, medical and pharmacological history of aloe. Bulletin of New York Academy of Medicine, 1990, 66:647–659.
20. Tizard AU et al. Effects of acemannan, a complex carbohydrate, on wound healing in young and aged rats. Wounds, a compendium of clinical research and practice, 1995, 6:201–209.
21. Roberts DB, Travis EL. Acemannan-containing wound dressing gels reduce radiation-induced skin reactions in C3H mice. International journal of radiation oncology, biology and physiology, 1995, 15:1047–1052.
22. Karaca K, Sharma JM, Norgren R. Nitric oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from Aloe vera. International journal of immunopharmacology, 1995, 17:183–188.
23. Winters WD, Benavides R, Clouse WJ. Effects of aloe extracts on human normal and tumor cells in vitro. Economic botany, 1981, 35:89–95.
24. Fujita K, Teradaira R. Bradykininase activity of aloe extract. Biochemical pharmacology, 1976, 25:205.
25. Udupa SI, Udupa AL, Kulkarni DR. Anti-inflammatory and wound healing properties of Aloe vera.Fitoterapia, 1994, 65:141–145.
26. Robson MC, Heggers J, Hagstrom WJ. Myth, magic, witchcraft or fact? Aloe vera revisited. Journal of burn care and rehabilitation, 1982, 3:157–162.
27. Collin C. Roentgen dermatitis treated with fresh whole leaf of Aloe vera. American journal of roentgen, 1935, 33:396–397.
28. Wright CS. Aloe vera in the treatment of roentgen ulcers and telangiectasis. Journal of the American Medical Association, 1936, 106:1363–1364.
29. Rattner H. Roentgen ray dermatitis with ulcers. Archives of dermatology and syphilogy, 1936, 33:593–594.
30. Loveman AB. Leaf of Aloe vera in treatment of roentgen ray ulcers. Archives of dermatology and syphilogy, 1937, 36:838–843.
31. Visuthikosol V et al. Effect of Aloe vera gel on healing of burn wounds: a clinical and histological study. Journal of the Medical Association of Thailand, 1995, 78:403–409.
32. Hormann HP, Korting HC. Evidence for the efficacy and safety of topical herbal drugs in dermatology: Part 1: Anti-inflammatory agents. Phytomedicine, 1994, 1:161– 171.
33. Hunter D, Frumkin A. Adverse reactions to vitamin E and Aloe vera preparations after dermabrasion and chemical peel. Cutis, 1991, 47:193–194.
34. Horgan DJ. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. Canadian Medical Association Journal, 1988, 138:336–338.
35. Morrow DM, Rappaport MJ, Strick RA. Hypersensitivity to aloe. Archives of dermatology, 1980, 116:1064–1065.
Further
A novel angiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol.
Aloe vera has marvelous medicinal properties. Scientists have discovered over 150 nutritional ingredients in Aloe vera. There seems to be no single magic ingredient. They all work together in a synergistic way to create healing and health giving benefits. The ten main areas of chemical constituents of Aloe vera include: amino acids, anthraquinones, enzymes, minerals, vitamins, lignins, monosaccharide, polysaccharides, salicylic acid, saponins, and sterols.33
The amino acids in Aloe vera are the building blocks of protein and influence our brain function. Humans require 22 amino acids and the body will make all of them except for eight essential amino acids which our body gets from the food/drinks that we take in. Every one of the essential amino acids are available in Aloe vera and they include isoleucine, leucine, lysine, methionine, phenylalanine, threonine, valine,and tryptophan. Some of the other non-essential amino acids found in Aloe vera include alanine, arginine, asparagine, cysteine, glutamic acid, glycine, histidine, proline, serine, tyrosine, glutamine, and aspartic acid.34
Located in the sap of the leaves you will find twelve anthraquinones, a phenolic compound that has stimulating effects on the bowels and antibiotic properties. In small amounts the anthraquinones do not have a purgative effect. They help with absorption from the gastro intestinal tract and have anti-microbial and pain killing effects. Too many anthraquinones can produce abdominal pain and diarrhea. The most important anthraquinones are aloin and emodin. They are anti-bacterial, anti-viral, and analgesic.35 The anthraquinones in Aloe vera breakup residue, pus and lifeless cells, bring blood to the region and flush out material from the wounds and ulcers.36
Enzymes act as biochemical catalysts that break down the proteins we eat into amino acids. The enzymes turn the food we eat into fuel for every cell in our body, enabling the cells to function and work efficiently. “The main enzymes found in Aloe vera include Amylase (breaks down sugars and starches), Bradykinase (stimulates immune system, analgesic, anti-inflammatory), Catalase (prevents accumulation of water in the body), Cellulase (aids digestion – cellulose), Lipase (aids digestion – fats), Oxidase, Alkaline Phosphatase, Proteolytiase (hydrolyses proteins into their constituent elements), Creatine Phosphokinase (aids metabolism), and Carboxypeptidase.”37
The next thing we need to ask ourselves is what fuels the enzymes? The key is the vitamins and minerals we take in. For instance if we lack in zinc and/or Vitamin B6, our body will not be able to break down or use protein. Because of the healing properties of Aloe vera and its synergistic action, the body receives what it needs to work properly. Aloe vera, an anti-oxidant rich plant, contains vitamins such as A, C, and E plus the minerals, zinc, and selenium. Anti-oxidants help boost the immune system and combat free radicals in the body.38
It also contains Vitamins B1, B2, B3, B5, B6, and B12 along with choline, calcium (teeth and bone formation, muscle contractions and heart health), magnesium(strengthens teeth and bones, maintains healthy muscles and nervous system, activates enzymes), zinc (speeds up wound healing, mental quickness assists with healthy teeth, bones, skin, immune system, and digestive aid), manganese (activates enzymes, builds healthy bones, nerves and tissues), chromium (assists with protein metabolism and balancing of blood sugars), selenium which all influence our brain performance.39
Additional minerals found in Aloe vera include copper (important for red blood cells, skin and hair pigment), iron (involved in oxygen transportation and making of hemoglobin in red blood cells), potassium (helps with fluid balance), phosphorus (helps build bones and teeth, assists with metabolism and body pH), and sodium (regulates body liquids, helps with nerve and muscle performance, and helps deliver nutrients into body cells).40 Aloe vera also contains the trace minerals of rhodium and iridium used in cancer and tumor research experiments.41
Another component of Aloe vera consists of the lignins, a major structural material of cellulose content, that allows for penetrative properties.42 Aloe vera can soak into the skin up to seven layers deep. Lignins penetrate the toughened areas of the skin being beneficial for skin problems such as eczema and psoriasis. 43
The next elements of Aloe vera we will discuss include monosaccharides and polysaccharides. Monosaccharides contain the simple sugars which include glucose. The polysaccharides are the more complex long-chain sugars involving glucose and mannose or the gluco-mannans. These sugars are ingested whole from the stomach. They do not get
broken down like other sugars, and appear in the bloodstream in exactly the same form. This process is known as pinocytosis. Once in the blood stream, they exert their healing and immuno-regulating effect. Some of these polysaccharides are not absorbed but stick to certain cells lining the gut and form a barrier preventing absorption of unwanted material so helping to prevent a leaking gut syndrome. The sugars are also used in moisturizing preparations.44
One polysaccharide, acemannan, is known for its ability to restore and boost the immune system by stimulating the production of macrophages and improving the activity of T-Lymphocytes by up to 50 %. Acemannan produces immune agents such as interferon and interleukin which help to destroy viruses, bacteria, and tumor cells.45 Acemannan improves cellular metabolism by normalizing cellular function and regulating the flow of nutrients and wastes in and out of the cells. It knows how to destroy parasites and fungus. In some AIDS patients, it even protected the immune system from the toxic side effects of AZT.46 Carrington Laboratories in the United States have separated the acemannan from Aloe vera. The product is sold as “Carrisyn” and is being used for treatment of AIDS and Feline leukemia.47
Many sources stated that Aloe vera has mucopolysaccharides, nitrogen containing polysaccharides, found in animals and bacteria.48 A regulation and testing board for Aloe vera products known as the International Aloe Science Council concludes that some people are misinformed and confused on terminology. The Aloe has polysaccharides but not mucopolysaccharides.49
Aloe vera contains salicylic acid which is an aspirin-like compound with anti -inflammatory, analgesic, and anti-bacterial properties. It has anti-pyretic properties for reducing fevers. Other constituents of Aloe vera would include prostaglandins, tannins, magnesium lactate, resins, mannins, proteins such as lectins, monosulfonic acid and gibberlin.50
Another constituent of Aloe vera includes saponins. These are soapy substances from the gel that is capable of cleansing and having antiseptic properties. The saponins perform strongly as anti-microbial against bacteria, viruses, fungi, and yeasts.51 The plant sterols or phyto-steroids in Aloe vera include Cholesterol, Campesterol, Lupeol, and B (Beta sign) Sitosterol.52 The plant steroids have fatty acids in them that have antiseptic, analgesic, and anti-inflammatory properties.53
Came across this:
Saline solution should soothe your eyes until you can find the cause and hopefully a cure. Here's the recipe I use: -28 oz. tap water (don't use filtered or bottled or distilled water because the pH will be lower and you'll need a different amount of salt) -1 tsp. table salt
I use an old visine bottle that I cleaned out to drip the saline solution into my eyes. The great thing about it is there is no limit to how often you can use it or how much to use at a time. All it is is salt water. I store the rest in a bottle in the fridge and use it to refill the visine bottle. Sometimes I can't believe how much better my eyes feel instantly after using the saline solution. I highly recommend that you at least try this out once. [Source]
Olopatadine hydrochloride is an antihistamine (as well as anticholinergic) and mast cell stabilizer.
Its 0.1% solution is sold in Australia as Patanol.
It is a relatively selective H1-receptor antagonist and inhibitor of histamine release from the mast cell. [Source]
Preservative: benzalkonium chloride (which is a problem).
What it does (academic studies)
FDA's clinical review (PDF) – this is very detailed.
Other studies
Both laboratory and clinical studies have established the efficacy, safety and comfort of olopatadine in several study design models and comparisons to other antiallergy medications. The application of olopatadine, specifically in the management of lid swelling, an allergic sign recalcitrant to therapy and nasal allergic symptoms has also been established. [Source]
The drug effectively relieves itching, redness, chemosis, tearing and lid swelling related to ocular allergy, and is also helpful in the management of nasal allergic symptoms. [Source]
My experience
My experience was not too bad, but there was only a very small improvement. Not worthwhile.
Ketorolac trometamol is a non-steroidal anti-inflammatory drug (NSAID) in the family of heterocyclic acetic acid derivative.
It is often used as an analgesic in preventing and reducing inflammation after eye surgery and relieving post-operative pain.
It works by blocking the production of certain chemicals that cause inflammation, pain, tenderness and swelling.
This medicine should only be used for three weeks at most. [Source]
Ketorolac acts by inhibiting the bodily synthesis of prostaglandins. It works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in producing prostaglandins, in response to injury or certain diseases, such as arthritis. These prostaglandins cause pain, swelling and inflammation. Ketorolac trometamol blocks the production of these prostaglandins and so is effective at relieving pain and inflammation. [Source]
Eye-drops are used to treat eye pain and to relieve the itchiness and burning of seasonal allergies. The ophthalmic formulation can be used instead of steroidal anti inflammatories in cases where a raised intraocular pressure (glaucoma) is to be avoided. [Source]
The preservative benzalkonium chloride found in the eye drops. This is often a cause of dry eyes, so the drops should be avoided if possible.
In my case Acular did NOT work. Patanol behaved much much better, but there was no cure.
Here's some info:
"Many people get dry eye because they have a potassium deficiency. This obviously can be cured by eating a banana" [Source]
"Eating a banana every day can be very useful, if you suffer from dry eyes. Since bananas are very rich in potassium, they help to control the balance of sodium and release of fluid in your cells, which results in preventing dry eyes. Simply eat banana a day and get rid of dry eyes." [Source]
Also: http://www.lookchem.com/Chempedia/Health-and-Chemical/15811.html
Make a banana face mask: http://www.ehow.com/how_2099414_make-banana-face-mask.html
This is work in progress, a placeholder.
Perhaps the best article: http://www.round-earth.com/HeadPainIntro.html
Over 20 muscles (primarily of the neck) refer pain to the head. Several refer pain specifically to the eye.
The 5th cranial nerve** called the Trigeminal nerve innervates the sensation to the face and is located in the upper neck region. Another cranial nerve, cranial nerve #2 innervates the sensation to the back of the head up to the top. Problems located in the upper neck region will often result in pain radiating up from the base of the skull/upper neck to the eyes and/or face [source]
"The neck muscle has pressure on the nerve Sub scapular (comes between C5 and C6), the nerve goes up into Sinusitis; from Sinusitis I have atypical Trigeminal Neuralgia. " [Source]
Trigeminal neuralgia (Tic douloureux)
This is the most prevalent disorder of the trigeminal nerve. It happens generally in middle and late ages and consists of extreme paroxysms of excruciating discomfort in the distribution of the mandibular and maxillary divisions and seldom in the Ophthalmic division. The attack rarely lasts over a minute, but it is so extreme that the patient winces. The attacks recur regularly for a number of weeks at a time and they are normally precipitated through stimuli applied to particular locations of the face, lips or tongue, or by way of movement of these components in chewing, speech or yawning (the cause zones). Commonly there is no demonstrable cause. At times trigeminal neuralgia may possibly be a symptom of involvement of the trigeminal nerve, in several sclerosis, basilar artery aneurysm or a tumor in the cerebellopontine angle. The symptomatic range really should be suspected in the presence of sensory involvement which is not a characteristic of idiopathic trigeminal neuralgia. [Source]
On 8 Nov visited my third eye specialist. Generally a competent person, but not clear how nerve compression can cause symptoms.
He SPECIFICALLY RULED OUT ALLERGY AND BACTERIAL INFECTION.
He also noted that mebomian glands are slightly blocked but otherwise fine.
The tear breakup was fine in the left eye but slightly quick in the right eye (but not conclusive).
The cornea was perfectly fine. No sign of inflammation. The rest of the eye was OK. Pressure in both eyes was 15.
So far four out of five doctors (including eye ear hospital and the last GP who seemed to be knowledgeable) who had made a detailed examination said I have or may have allergy, one (on 8 Nov) has ruled it out.
Four out of five doctors said I have inflammation but one says I don't have any inflammation.
One out of five doctors said I might have blepharitis. Two have specifically ruled it out.
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