September 18, 2011
Antibiotics used in the eye
Common antibiotics used in treating eye problems are sulfacetamide, erythromycin, gentamicin, ofloxacin, tobramycin, and ciprofloxacin [Source]
doxycycline – for Blepharitis
AzaSite (azithromycin 1% ophthalmic solution).
Available as Zithromax in
AzaSite not only attacks the most common pathogens, namely Staphylococcus, Streptococcus, and Hemophilus, but it adds the additional action of interrupting the inflammatory cascade. It suppresses cytokines and chemokines and other inflammatory constituents, and it reduces matrix metalloproteinase (MMP). It does all this anti-inflammatory activity without the risk of slowing the healing process or higher intraocular pressure that comes with topical corticosteroids.
Another benefit I’ve found with AzaSite is its seven-day dosing schedule for bacterial conjunctivitis. The regimen is only nine drops—two a day for the first two days, then once a day for the remaining five days. Typically, topical antibacterials require four-times-a-day application, if not more, for a loading dose. Compliance is a big issue, especially with younger children, but AzaSite’s simplified dosing schedule resolves that in many cases. [Source]
Thursday, 25 September 2008 22:00
Results from two single-center studies indicate that topical azithromycin 1% ophthalmic solution (AzaSite) shows potential as a safe, well-tolerated and highly effective treatment for meibomian gland disease (posterior blepharitis) and anterior blepharitis.
One study of 21 patients showed that the compound, in combination with warm compresses, provided a significantly greater clinical benefit than warm compresses alone in treating the signs and symptoms of posterior blepharitis, and that patients rated efficacy with azithromycin in combination with warm compresses as better than warm compresses alone.
Another study evaluated azithromycin 1% for use in treating chronic, mixed (Staphylococcal and seborrheic) anterior blepharitis using an off-label administration technique involving direct application to the eyelids. The results showed that azithromycin ophthalmic solution was better than erythromycin in treating signs and symptoms of anterior blepharitis.