September 15, 2011
Dry eye research: Remedies under development for dry eyes
RGN-259 has been shown to reduce ocular surface defects associated with dry eye syndrome in two animal models when compared to both positive and negative controls. In one experiment, RGN-259 performed better than Restasis™ in reducing such damage. [Source]
Unfortunately in phase 2 trial, it has not done well (see this)
The trial demonstrated statistically significant improvements in signs and symptoms with its doses of MIM-D3. Mimetogen is in the process of completing its analysis of the data, and intends to present further details at a future medical conference.
The 150-patient phase II study utilized a controlled adverse environment (CAETM) chamber to measure dry eye patients’ ability to withstand a stressful drying environment on the eye, and patient diaries to measure the severity of their dry eye symptoms over the course of the study. Patients were randomized to receive MIM-D3 low dose, MIM-D3 high dose or placebo twice/day over the course of a 28-day study.
EyeGate, Novagali, Resolvyx and SARcode all have therapies under development and are currently in Phase 3 of FDA approval.
Lipiflow endorsed by FDA. (also this) [LipiFlow® Thermal Pulsation System for the treatment of meibomian gland dysfunction (MGD). TearScience’s integrated, in-office system addresses a root cause of evaporative dry eye, the obstructed glands. By assessing the tear film and meibomian gland function, physicians can determine whether MGD is the primary cause of a patient’s evaporative dry eye and whether a patient is a good candidate for the LipiFlow® treatment. [Source]
SAR 1118 is a first-in-class molecule that inhibits T-cell inflammation by blocking the binding of two key cellular surface proteins (LFA-1 and ICAM-1) that mediate the chronic inflammatory cascade. SAR 1118 may be able to reduce inflammation associated with dry eye disease. [Source]
Research projects in dry eye syndrome volume editor, Horst Brewitt, Published: Basel [Switzerland] ; New York: Karger, c2010. Summary: Offered to Prof. Behrens-Baumann, the director of the U. of Magdeburg Eye Clinic, as a 65th birthday festschrift, this collection of 14 articles presents current research on diagnosis and treatment of dry eye syndrome, by ophthalmologists based mainly in Germany. The chapter topics include possible use of trefoil factor family peptide 3 at the ocular surface, the importance of the lid marigin in ocular surface health, generation of two-and three-dimensional lacrimal gland constructs, and the diagnostic markers of Sjögren's syndrome. The articles are written for other specialists in the field. Each includes an abstract, list of references, and drawings and clinical photos in b&w plates of the best quality. Annotation ©2010 Book News, Inc., Portland, OR (booknews.com)
Contents: Trefoil factor family peptide 3 at the ocular surface / Schulze, U.; Sel, S.; Paulsen, F.P. — Cationic amino acid transporters and [beta]-defensins in dry eye syndrome / Jäger, K. … [et al.] — Antimicrobial peptides as a major part of the innate immune defense at the ocular surface / Garreis, F.; Gottschalt, M.; Paulsen, F.P. — Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT) / Knop, N.; Knop, E. — Intravital multidimensional real-time imaging of the conjunctival immune system / Gehlsen, U.; Hüttmann, G.; Steven, P. — Generation of two- and three-dimensional lacrimal gland constructs / Schrader, S. … [et al.] — Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency / Pauklin, M. … [et al.] — Laser scanning confocal microscopy for conjunctival epithelium imaging / Jürgens, C. … [et al.] — Pollen enzymes degrade human tear fluid and conjunctival cells : an approach to understanding seasonal non-allergic conjunctivitis / Rabensteiner, D.F. … [et al.] — Towards a new in vitro model of dry eye : the ex vivo eye irritation test / Spöler, F.; Frentz, M.; Schrage, N.F. — The lid margin is an underestimated structure for preservation of ocular surface health and development of dry eye disease / Knop, E. … [et al.] — Diagnostic markers of sjögren?s syndrome / Witte, T. — Hyperosmolarity of the tear film in dry eye syndrome / Messmer, E.M.; Bulgen, M.; Kampik, A. — Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action / Springs, C.